Reply: Does dominant pedunculopontine nucleus exist?

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Reply: Does dominant pedunculopontine nucleus exist? Probably not.

Sir, We are pleased to continue the discussion with regards to our recent manuscript detailing altered structural connectivity of the locomotor network within the right hemisphere of individuals with Parkinson’s disease who experience freezing of gait (Fling et al., 2013). Our previous work has asserted the possibility of right hemisphere pathology as a principal neural component underlying fre...

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LETTER TOTHE EDITOR Reply: Does dominant pedunculopontine nucleus exist?

Sir, We appreciate the thoughtful comments and additional contributions from Lam and colleagues with regards to our recent manuscript in Brain, which demonstrated substantial asymmetry of structural connectivity strength within the locomotor network of individuals with Parkinson’s disease who experience freezing of gait (FOG+ ) (Fling et al., 2013). Specifically, we reported reduced white matte...

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LETTER TOTHE EDITOR Does dominant pedunculopontine nucleus exist?

Sir, We read with great interest the paper by Fling et al. (2013) recently published in Brain. In this imaging study, patients with Parkinson’s disease with freezing of gait (FOG), without FOG, and age-matched controls were studied with diffusion tensor imaging to identify group and inter-hemispheric differences of tract quality and quantity in the pedunculopontine nucleus (PPN) network. Intere...

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LETTER TOTHE EDITOR Does dominant pedunculopontine nucleus exist? Probably not

Sir, We have followed with interest the recent discussion in Brain regarding the possibility of a ‘dominant’ right-hemispheric pedunculopontine nucleus pathology in freezing of gait in Parkinson’s disease (Fling et al., 2013, 2014; Lam et al., 2014). In the original study, Fling et al. (2013) used diffusion weighted imaging to demonstrate the presence of abnormal connectivity between the fronta...

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LETTER TOTHE EDITOR Reply: Does dominant pedunculopontine nucleus exist? Probably not

Sir, We are pleased to continue the discussion with regards to our recent manuscript detailing altered structural connectivity of the locomotor network within the right hemisphere of individuals with Parkinson’s disease who experience freezing of gait (Fling et al., 2013). Our previous work has asserted the possibility of right hemisphere pathology as a principal neural component underlying fre...

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ژورنال

عنوان ژورنال: Brain

سال: 2014

ISSN: 1460-2156,0006-8950

DOI: 10.1093/brain/awu226